Evaluation of the Anti-Diabetic Property of Methanol Bark Extract of Detarium Senegalense on Brain Catalase and Superoxide Dismutase in Alloxan-Induced Diabetic Wistar Rats

ABSTRACT

Detarium senegalense is a priority fruit species exploited but little known and under-valued in West African countries. The activities of superoxide dismutase and catalase were measured in subcellular fractions of homogenates prepared from the brain of diabetic male wistar rats treated with methanol bark extract of Detarium senegalense. Diabetes was induced by intraperitonial injection of alloxan monohydrate. The blood glucose levels and body weight also were analyzed as indices of diabetes. After 7 days, alloxan monohydrate increased the blood glucose level (P<0.05) of rats indicating hyperglycaemia. Treatment of the rats with extract (250 mg/kg, 500mg/kg and 1000 mg/kg) of Detarium senegalense decreased the blood glucose level significantly (P<0.05) within 7-21days of treatment. This study concludes that the methanol bark extract of Detarium senegalense can be used as traditional treatment for diabetes mellitus as claimed by local users.

Keywords: Diabetes mellitus, Detarium senegalense, Wistar rat, Alloxan.